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Scientific Research On Cellular Nutrients in Fighting Cancer

Clinical Studies on Cellular Nutrients

Megadose vitamins in bladder cancer: a double-blind clinical trial.
J Urol 1994 Jan;151(1):21-6
Lamm DL; Riggs DR; Shriver JS; van Gilder PF; Rach JF; De Haven JI

L-arginine stimulates host defenses in patients with breast cancer.
Surgery 1994 Feb;115(2):205-12   
Brittenden J; Park KG; Heys SD; Ross C; Ashby J; Ah-See A; Eremin O

A population-based case-control study of carotenoid and vitamin A intake and ovarian cancer (United States).
Cancer Causes Control 2001 Jan;12(1):83-90   
Bertone ER; Hankinson SE; Newcomb PA; Rosner B; Willet WC; Stampfer MJ; Egan KM

Influence of drinking green tea on breast cancer malignancy among Japanese patients.
Jpn J Cancer Res 1998 Mar;89(3):254-61
Nakachi K; Suemasu K; Suga K; Takeo T; Imai K; Higashi Y

Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden
Int J Cancer 2000 Jul 1;87(1):133-40
Ekstrom AM; Serafini M; Nyren O; Hansson LE; Ye W; Wolk A

Dietary carotenoids and vitamins A, C, and E and risk of breast cancer.
J Natl Cancer Inst 1999 Mar 17;91(6):547-56
Zhang S; Hunter DJ; Forman MR; Rosner BA; Speizer FE; Colditz GA; Manson JE; Hankinson SE; Willett WC

A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review.
Cancer Detect Prev 2000;24(1):91-9
Fujiki H; Suganuma M; Okabe S; Sueoka E; Suga K; Imai K; Nakachi K

Two stages of cancer prevention with green tea.
J Cancer Res Clin Oncol 1999 Nov;125(11):589-97
Fujiki H

Cancer inhibition by green tea.
Mutat Res 1998 Jun 18;402(1-2):307-10
Fujiki H; Suganuma M; Okabe S; Sueoka N; Komori A; Sueoka E; Kozu T; Tada Y; Suga K; Imai K; Nakachi K

Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States).
Cancer Causes Control 2002 May;13(4):373-82
Arts IC; Jacobs DR; Gross M; Harnack LJ; Folsom AR

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance.
Br J Cancer 1982 Sep;46(3):354-67   
Anthony HM; Schorah CJ

Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of the consumption of food with an elevated content of this vitamin
Nutr Hosp 1995 Nov-Dec;10(6):368-72    
Nunez Martin C ; Ortiz de Apodaca y Ruiz A
Servicio de Bioquimica, Hospital Virgen de la Salud, Toledo, Espana.

Endogenous urinary 3-hydroxyproline has 96% specificity and 44% sensitivity for cancer screening.
J Lab Clin Med 1992 Dec;120(6):908-20   
Okazaki I ; Matsuyama S ; Suzuki F; Maruyama K; Maruta A; Kubochi K; Yoshino K; Kobayashi Y; Abe O; Tsuchiya M
Department of Preventive Medicine, School of Medicine, Keio University, Tokyo, Japan

Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract.
Eur J Clin Nutr 2001 Apr;55(4):293-7      
Federico A; Iodice P; Federico P; Del Rio A; Mellone MC; Catalano G; Federico P
Semeiotics and Clinical Methodology, II University of Naples, Naples, Italy.

The relationship of dietary selenium and breast cancer.
J Surg Oncol 1980;15(1):67-70
McConnell KP; Jager RM; Bland KI ; Blotcky AJ

Reduction of cancer mortality and incidence by selenium supplementation.
Med Klin (Munich) 1997 Sep 15;92 Suppl 3:42-5
Combs GF; Clark LC; Turnbull BW

Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China.
Sun CL, Yuan JM, Lee MJ, Yang CS, Gao YT, Ross RK, Yu MC.
USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. canlan@hsc.usc.edu

Research Data on Cellular Nutrients

Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol.
Roy M, Chakrabarty S, Sinha D, Bhattacharya RK, Siddiqi M.

Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.
Br J Urol 1998 May;81(5):730-4   
Clark LC; Dalkin B; Krongrad A; Combs GF; Turnbull BW; Slate EH; Witherington R; Herlong JH; Janosko E; Carpenter D; Borosso C; Falk S; Rounder J

Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells.
Toxicol Appl Pharmacol 2000 Apr 1;164(1):82-90   
Gupta S; Ahmad N; Nieminen AL; Mukhtar H

Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells.
Life Sci 2001 Jan 26;68(10):1207-14   
Chung LY; Cheung TC; Kong SK; Fung KP; Choy YM; Chan ZY; Kwok TT

Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction.
Carcinogenesis 2000 Nov;21(11):2035-9   
Yang GY; Liao J; Li C; Chung J; Yurkow EJ; Ho CT; Yang CS

Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis.
Mol Pharmacol 2002 Oct;62(4):765-71   
Kazi A; Smith DM; Zhong Q; Dou QP

Induction of p57 is required for cell survival when exposed to green tea polyphenols.
Anticancer Res 2002 Nov-Dec;22(6C):4115-20   
Hsu S; Yu FS; Lewis J; Singh B; Borke J; Osaki T; Athar M; Schuster G

Green tea polyphenol epigallocatechin-3 gallate induces apoptosis of proliferating vascular smooth muscle cells via activation of p53.
FASEB J 2003 Apr;17(6):702-4   
Hofmann CS; Sonenshein GE

Selenium effects on prostate cell growth.
Cancer Epidemiol Biomarkers Prev 2000 Nov;9(11):1171-82
Menter DG; Sabichi AL; Lippman SM

P53 gene of chang-liver cells (Atcc-Ccl13) exposed to aflatoxin B1 (Afb): the effect of lysine on mutation at codon 249 of exon 7.
Afr J Med Med Sci. 1999 Mar-Jun;28(1-2):71-5.
Uwaifo O.

Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
Dermatologica. 1987;175(4):183-90
Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A.

Amino acid deficiency up-regulates specific mRNAs in murine embryonic cells.
J Nutr. 2002 Aug;132(8):2137-42
Fontanier-Razzaq N, Harries DN, Hay SM, Rees WD.

Identification and characterization of amino acid starvation-induced CD24 gene in MCF-7 human breast cancer cells.
Int J Oncol. 2000 May;16(5):1049-54
Liu W, Vadgama JV.

Retinoids and differentiation treatment: a strategy for treatment in cancer.
Anticancer Res 1994 Nov-Dec;14(6A):2339-46   
Cornic M; Agadir A; Degos L; Chomienne C

Vitamins and cancer.
Cancer Lett 1997 Mar 19;114(1-2):195-202   
van Poppel G; van den Berg H

Anticarcinogenic effects of (-)-epigallocatechin gallate.
Prev Med 1992 Jul;21(4):503-9
Fujiki H; Yoshizawa S; Horiuchi T; Suganuma M; Yatsunami J; Nishiwaki S; Okabe S; Nishiwaki-Matsushima R; Okuda T; Sugimura T

Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines.
Jpn J Cancer Res 1999 Jul;90(7):733-9   
Okabe S; Ochiai Y; Aida M; Park K; Kim SJ; Nomura T; Suganuma M; Fujiki H

Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds.
Cancer Lett 1995 Aug 16;95(1-2):221-5 
Menon LG; Kuttan R; Kuttan G

Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents.
Biochem Pharmacol 2000 Oct 15;60(8):1051-9   
Agarwal R

Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells.
J Agric Food Chem 2003 Mar 26;51(7):1858-63   
Maeda-Yamamoto M; Suzuki N; Sawai Y; Miyase T; Sano M; Hashimoto-Ohta A; Isemura M

Inhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea.
Int J Urol 1999 Feb;6(2):93-9   
Sato D

Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Jpn J Cancer Res 1996 Oct;87(10):1034-8   
Matsumoto N; Kohri T; Okushio K; Hara Y

Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.
Breast Cancer Res Treat 1994;30(3):233-42   
Bhide SV; Azuine MA; Lahiri M; Telang NT

Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells.
Cell Biol Int 1993 Jun;17(6):559-64   
Isemura M; Suzuki Y; Satoh K; Narumi K; Motomiya M

Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells.
Oncogene 2000 Apr 6;19(15):1924-32   
Ren F; Zhang S; Mitchell SH; Butler R; Young CY

Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas.
Nutr Cancer 2000;38(2):265-73   
Zhang G; Miura Y; Yagasaki K

Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells.
Biochim Biophys Acta 2002 Jan 30;1542(1-3):209-20   
Annabi B; Lachambre MP; Bousquet-Gagnon N; Page M; Gingras D; Beliveau R

(-)-Epigallocatechin gallate, the main constituent of Japanese green tea, inhibits tumor promotion of okadaic acid
Fukuoka Igaku Zasshi 1996 Oct;87(10):215-21   
Yoshizawa S

Anti-metastatic activity of curcumin and catechin.
Cancer Lett 1999 Jul 1;141(1-2):159-65   
Menon LG; Kuttan R; Kuttan G

Growth inhibition of leukemic cells by (-)-epigallocatechin gallate, the main constituent of green tea
Life Sci 1998;63(16):1397-403   
Otsuka T; Ogo T; Eto T; Asano Y; Suganuma M; Niho Y

Chemopreventive effects of green tea polyphenols correlate with reversible induction of p57 expression
Anticancer Res 2001 Nov-Dec;21(6A):3743-8   
Hsu S; Lewis JB; Borke JL; Singh B; Dickinson DP; Caughman GB; Athar M; Drake L; Aiken AC; Huynh CT; Das BR; Osaki T; Schuster GS

Inhibitory effect of green tea extract on the process of pancreatic carcinogenesis induced by N-nitrosobis-(2-oxypropyl)amine (BOP) and on tumor promotion after transplantation of N-nitrosobis-(2-hydroxypropyl)amine (BHP)-induced pancreatic cancer in Syrian hamsters
Pancreas 1997 Oct;15(3):272-7   
Hiura A; Tsutsumi M; Satake K

Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins
Biosci Biotechnol Biochem 1997 Sep;61(9):1504-6   
Sazuka M; Imazawa H; Shoji Y; Mita T; Hara Y; Isemura M

Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate
Cancer 2001 Feb 15;91(4):822-32   
Garbisa S; Sartor L; Biggin S; Salvato B; Benelli R; Albini A

Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin)
J Biochem (Tokyo) 2003 May;133(5):571-6   
Oneda H; Shiihara M; Inouye K

Tea catechins and related polyphenols as anti-cancer agents
Biofactors 2000;13(1-4):81-5   
Isemura M; Saeki K; Kimura T; Hayakawa S; Minami T; Sazuka M

Inhibition of fibroblast growth factors by green tea
Int J Oncol 2002 Sep;21(3):487-91   
Sartippour MR; Heber D; Zhang L; Beatty P; Elashoff D; Elashoff R; Go VL; Brooks MN

Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production
Nutr Cancer 2001;41(1-2):119-25   
Tang FY; Meydani M

Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients
Jpn J Cancer Res 2000 Jan;91(1):34-40   
Li HC; Yashiki S; Sonoda J; Lou H; Ghosh SK; Byrnes JJ; Lema C; Fujiyoshi T; Karasuyama M; Sonoda S

The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG).
Amino Acids 2002;22(2):131-43   
Wang YC; Bachrach U

Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX)
Pharmacol Toxicol 2003 May;92(5):234-41   
Morre DJ; Morre DM; Sun H; Cooper R; Chang J; Janle EM

Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro.
Chem Biol Interact 1998 Apr 3;110(3):159-72   
Kennedy DO; Nishimura S; Hasuma T; Yano Y; Otani S; Matsui-Yuasa I

Potent inhibitory action of red wine polyphenols on human breast cancer cells.
J Cell Biochem 2000 Jun 6;78(3):429-41   
Damianaki A; Bakogeorgou E; Kampa M; Notas G; Hatzoglou A; Panagiotou S; Gemetzi C; Kouroumalis E; Martin PM; Castanas E

Green tea: cancer preventive beverage and/or drug.
Cancer Lett 2002 Dec 15;188(1-2):9-13   
Fujiki H; Suganuma M; Imai K; Nakachi K

Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells.
Cancer Res 2002 Feb 1;62(3):652-5   
Pianetti S; Guo S; Kavanagh KT; Sonenshein GE

Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer.
Altern Med Rev 1999 Oct;4(5):360-70   
Brown MD

Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate.
Biochem Biophys Res Commun 2000 Aug 28;275(2):328-34
Ahmad N; Cheng P; Mukhtar H

Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells.
Arch Biochem Biophys 2000 Apr 15;376(2):338-46   
Ahmad N; Gupta S; Mukhtar H

Green Tea Constituent (-)-Epigallocatechin-3-Gallate Inhibits Hep G2 Cell Proliferation and Induces Apoptosis through p53-Dependent and Fas-Mediated Pathways [In Process Citation]
J Biomed Sci 2003 Mar-Apr;10(2):219-27  
Kuo PL; Lin CC

Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallate.
Arch Biochem Biophys 2002 Feb 1;398(1):125-31   
Ahmad N; Adhami VM; Gupta S; Cheng P; Mukhtar H

Matrix metalloproteinase inhibition by green tea catechins.
Biochim Biophys Acta 2000 Mar 16;1478(1):51-60
Demeule M; Brossard M; Page M; Gingras D; Beliveau R

Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate.
Cancer Lett 1998 Aug 14;130(1-2):1-7   
Paschka AG; Butler R; Young CY

Induction of apoptosis by the green tea flavonol (-)-epigallocatechin-3-gallate in human endothelial ECV 304 cells.
Anticancer Res 2002 Nov-Dec;22(6A):3373-8   
Yoo HG; Shin BA; Park JC; Kim HS; Kim WJ; Chay KO; Ahn BW; Park RK; Ellis LM; Jung YD

Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture.
J Cell Biochem 2001;82(3):387-98   
Kavanagh KT; Hafer LJ; Kim DW; Mann KK; Sherr DH; Rogers AE; Sonenshein GE

Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade.
Biochem Pharmacol 1999 Sep 15;58(6):911-5   
Lin JK; Liang YC; Lin-Shiau SY

Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines.
Clin Cancer Res 2001 Dec;7(12):4220-9   
Masuda M; Suzui M; Weinstein IB

Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.
Anticancer Res 2003 Mar-Apr;23(2B):1533-9   
Hsu S; Lewis J; Singh B; Schoenlein P; Osaki T; Athar M; Porter AG; Schuster G

Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells.
Biochem Biophys Res Commun 2000 Apr 21;270(3):793-7   
Islam S; Islam N; Kermode T; Johnstone B; Mukhtar H; Moskowitz RW; Goldberg VM; Malemud CJ; Haqqi TM

Epigallocatechin gallate protects U937 cells against nitric oxide-induced cell cycle arrest and apoptosis.
J Cell Biochem 2001;81(4):647-58   
Kelly MR; Geigerman CM; Loo G

Green tea polyphenol epigallocatechin-3 gallate induces apoptosis of proliferating vascular smooth muscle cells via activation of p53.
FASEB J 2003 Apr;17(6):702-4   
Hofmann CS; Sonenshein GE

Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells.
Redox Rep 2002;7(3):171-7   
Nie G; Cao Y; Zhao B

Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability, and DNA synthesis.
Prostate 1997 Aug 1;32(3):188-95   
Maramag C; Menon M; Balaji KC; Reddy PG; Laxmanan S

Effect of vitamin C on androgen independent prostate cancer cells (PC3 and Mat-Ly-Lu) in vitro: involvement of reactive oxygen species-effect on cell number, viability and DNA synthesis.
Cancer Biochem Biophys 1998 Jun;16(1-2):17-30
Menon M; Maramag C; Malhotra RK; Seethalakshmi L

Combined vitamins B12b and C induce the glutathione depletion and the death of epidermoid human larynx carcinoma cells HEp-2.
Biosci Rep 2000 Oct;20(5):411-7   
Akatov VS; Evtodienko YV; Leshchenko VV; Teplova VV; Potselueva MM; Kruglov AG; Lezhnev EI; Yakubovskaya RI

Antimetastatic and anti-invasive ability of phospho-ascorbyl palmitate through intracellular ascorbate enrichment and the resultant antioxidant action
Oncol Res 1999;11(10):479-87   
Liu JW; Nagao N; Kageyama K; Miwa N

Inhibitory effect of dietary arginine on growth of Ehrlich ascites tumor cells in mice.
J Nutr 1979 Mar;109(3):489-94   
Milner JA; Stepanovich LV

Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats.
Biofactors 2001;15(1):11-26   
Davis CD; Johnson WT

(-)-Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: inhibitory effects against biochemical events and tumor initiation in Sencar mouse skin.
Nutr Cancer 1992;18(1):73-83 
Katiyar SK; Agarwal R; Wang ZY; Bhatia AK; Mukhtar H

Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells.
Prostate 2001 Feb 1;46(2):98-107
Bhatia N; Agarwal R

Green tea and its catechins inhibit breast cancer xenografts.
Nutr Cancer 2001;40(2):149-56
Sartippour MR; Heber D; Ma J; Lu Q; Go VL; Nguyen M

(-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice.
Carcinogenesis 2000 May;21(5):915-9
Mimoto J; Kiura K; Matsuo K; Yoshino T; Takata I; Ueoka H; Kataoka M; Harada M

(-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts.
Breast Cancer Res Treat 2002 Dec;76(3):195-201
Vergote D; Cren-Olive C; Chopin V; Toillon RA; Rolando C; Hondermarck H; Le Bourhis X

Gene expression profile in human prostate LNCaP cancer cells by (--) epigallocatechin-3-gallate.
Cancer Lett 2002 Aug 8;182(1):43-51
Wang SI; Mukhtar H

Green tea and prostate cancer.
Urol Clin North Am 2002 Feb;29(1):49-57, viii
Gupta S; Mukhtar H

Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).
Mol Biol Cell 1999 Apr;10(4):1093-104
Ahn HY; Hadizadeh KR; Seul C; Yun YP; Vetter H; Sachinidis A

Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells.
Cancer Lett 1995 Nov 27;98(1):27-31
Sazuka M; Murakami S; Isemura M; Satoh K; Nukiwa T

Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea.
Int J Exp Pathol 2001 Dec;82(6):309-16   
Jung YD; Ellis LM

Novel approaches to chemoprevention of skin cancer.
J Dermatol. 2000 Nov;27(11):691-5.
Bickers DR, Athar M.

A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression.
DNA Cell Biol 2003 Mar;22(3):217-24
Ahn WS; Huh SW; Bae SM; Lee IP; Lee JM; Namkoong SE; Kim CK; Sin JI

Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro.
Anticancer Res 2000 Sep- Oct;20(5B):3459-65
Elattar TM; Virji AS

Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells.
Oncogene 2003 Jul 31;22(31):4851-9
Hastak K; Gupta S; Ahmad N; Agarwal MK; Agarwal ML; Mukhtar H

Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells.
Arch Biochem Biophys 2003 Feb 1;410(1):177-85
Gupta S; Hussain T; Mukhtar H

Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols.
Jpn J Cancer Res 1997 Jul;88(7):639-43
Okabe S; Suganuma M; Hayashi M; Sueoka E; Komori A; Fujiki H

Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate.
J Urol 2003 Sep;170(3):773-6
Kemberling JK; Hampton JA; Keck RW; Gomez MA; Selman SH

Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.
Cancer Res 2003 Feb 15;63(4):824-30
Naasani I; Oh-Hashi F; Oh-Hara T; Feng WY; Johnston J; Chan K; Tsuruo T

Chemoprevention of oral cancer by green tea.
Gen Dent 2002 Mar-Apr;50(2):140-6
Hsu SD; Singh BB; Lewis JB; Borke JL; Dickinson DP; Drake L; Caughman GB; Schuster GS

Green tea and cancer chemoprevention.
Mutat Res 1999 Jul 16;428(1-2):339-44
Suganuma M; Okabe S; Sueoka N; Sueoka E; Matsuyama S; Imai K; Nakachi K; Fujiki H

Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate.
Cancer Lett 1995 Sep 25;96(2):239-43
Liao S; Umekita Y; Guo J; Kokontis JM; Hiipakka RA

Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/HeNCrj mice and human hepatoma-derived PLC/PRF/5 cells.
Jpn J Cancer Res 1994 Mar;85(3):221-5
Nishida H; Omori M; Fukutomi Y; Ninomiya M; Nishiwaki S; Suganuma M; Moriwaki H; Muto Y

Anticarcinogenic activity of green tea polyphenols.
Jpn J Clin Oncol 1993 Jun;23(3):186-90
Komori A; Yatsunami J; Okabe S; Abe S; Hara K; Suganuma M; Kim SJ; Fujiki H

Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.
Cancer Res 1992 Jul 1;52(13):3582-8
Agarwal R; Katiyar SK; Zaidi SI; Mukhtar H

Progress in studies on the antimutagenicity and anticarcinogenicity of green tea epicatechins.
Chin Med Sci J 1991 Dec;6(4):233-8
Cheng S; Ding L; Zhen Y; Lin P; Zhu Y; Chen Y; Hu X

Molecular targets for green tea in prostate cancer prevention.
J Nutr 2003 Jul;133(7 Suppl):2417S-2424S
Adhami VM; Ahmad N; Mukhtar H

Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.
Pancreas 2002 Jul;25(1):45-8   
Takada M; Nakamura Y; Koizumi T; Toyama H; Kamigaki T; Suzuki Y; Takeyama Y; Kuroda Y

Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1.
Int J Oncol 2002 Jun;20(6):1233-9
Fujimoto N; Sueoka N; Sueoka E; Okabe S; Suganuma M; Harada M; Fujiki H

Biochemical changes in the connective tissue components of malignant tumors and lungs in mice during metastatic spreading and chemotherapy
Vopr Med Khim 1989 Sep-Oct;35(5):30-4
Chubinskaia SG; Sevast'ianova NA; Veksler IG; Slutskii LI

Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines.
Anticancer Res 1998 Jul-Aug;18(4A):2487-93
Koh WS; Lee SJ; Lee H; Park C; Park MH; Kim WS; Yoon SS; Park K; Hong SI; Chung MH; Park CH
Department of Medicine, Samsung Medical Center, Kangnam-ku Seoul, Korea.    

Tea polyphenols: prevention of cancer and optimizing health
Am J Clin Nutr 2000 Jun;71(6 Suppl):1698S-702S; discussion 1703S-4S
Mukhtar H; Ahmad N
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA
hxm4@po.cwru.edu .

Activation mechanisms of matrix metalloproteinases.
Biol Chem 1997 Mar-Apr;378(3-4):151-60    
Nagase H
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160, USA.

Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines.
Anticancer Drugs 1996 Jun;7(4):461-8    
Valcic S ; Timmermann BN; Alberts DS; Wachter GA; Krutzsch M; Wymer J; Guillen JM
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721, USA.

Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols.
Carcinogenesis 1998 Apr;19(4):611-6    
Yang GY; Liao J; Kim K; Yurkow EJ; Yang CS
Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789, USA.

Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells.
Carcinogenesis 2003 Aug;24(8):1369-78
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Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells.
J Cell Biochem 1997 Oct 1;67(1):55-65    
Liang YC; Lin-shiau SY; Chen CF; Lin JK
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Republic of China.

Matrix metalloproteinase inhibition by green tea catechins.
Biochim Biophys Acta 2000 Mar 16;1478(1):51-60    
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Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.
J Natl Cancer Inst 1997 Dec 17;89(24):1881-6    
Ahmad N; Feyes DK; Nieminen AL; Agarwal R; Mukhtar H
Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Anti-metastatic effect of an autooxidation-resistant and lipophilic ascorbic acid derivative through inhibition of tumor invasion
Anticancer Res 2000 Jan-Feb;20(1A):113-8    
Liu JW; Nagao N; Kageyama K; Miwa N
Department of Cell Biochemistry, Hiroshima Prefectural University School of BioSciences, Japan.

Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives.
Cancer Lett 1998 Jan 9;122(1-2):93-9
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Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306, USA

Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro.
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Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake.
Mol Carcinog 1999 Dec;26(4):213-25    
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Inhibition of aminopeptidase N (AP-N) and urokinase-type plasminogen activator (uPA) by zinc suppresses the invasion activity in human urological cancer cells.
Biol Pharm Bull 2001 Mar;24(3):226-30    
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Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Japan.

Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer.
Prostate 1998 Jun 1;35(4):285-96    
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Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.
J Natl Cancer Inst 2001 Oct 17;93(20):1525-33    
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Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines.
J Endocrinol 2001 May;169(2):417-24    
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Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan.

Effect of zinc on immune functions and host resistance against infection and tumor challenge.
Immunopharmacol Immunotoxicol 1992;14(4):813-40    
Singh KP; Zaidi SI; Raisuddin S; Saxena AK; Murthy RC; Ray PK
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India

Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
Clin Cancer Res 2002 Nov;8(11):3579-83    
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The effect of trace elements--especially zinc--on metastasizing of Lewis lung tumor
Orv Hetil 1999 Dec 19;140(51):2869-71    
Timar J; Paku S; Kopper L
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Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat.
J Natl Cancer Inst 1980 Dec;65(6):1299-301    
Thompson HJ; Becci PJ